Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow
L Wang, M Xiang, Y Liu, N Sun, M Lu, Y Shi, X Wang… - …, 2016 - pubs.aip.org
Endothelial cells (ECs) have great potential in vascular diseases research and regenerative
medicine. Autologous human ECs are difficult to acquire in sufficient numbers in vitro, and
human induced pluripotent stem cells (iPSCs) offer unique opportunity to generate ECs for
these purposes. In this work, we present a new and efficient method to simply differentiate
human iPSCs into functional ECs, which can respond to physiological level of flow and
inflammatory stimulation on a fabricated microdevice. The endothelial-like cells were …
medicine. Autologous human ECs are difficult to acquire in sufficient numbers in vitro, and
human induced pluripotent stem cells (iPSCs) offer unique opportunity to generate ECs for
these purposes. In this work, we present a new and efficient method to simply differentiate
human iPSCs into functional ECs, which can respond to physiological level of flow and
inflammatory stimulation on a fabricated microdevice. The endothelial-like cells were …