The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior
A Stengel, H Karasawa, Y Taché - Hormones and behavior, 2015 - Elsevier
Somatostatin was discovered four decades ago as hypothalamic factor inhibiting growth
hormone release. Subsequently, somatostatin was found to be widely distributed throughout
the brain and to exert pleiotropic actions via interaction with five somatostatin receptors (sst
1–5) that are also widely expressed throughout the brain. Interestingly, in contrast to the
predominantly inhibitory actions of peripheral somatostatin, the activation of brain sst 2
signaling by intracerebroventricular injection of stable somatostatin agonists potently …
hormone release. Subsequently, somatostatin was found to be widely distributed throughout
the brain and to exert pleiotropic actions via interaction with five somatostatin receptors (sst
1–5) that are also widely expressed throughout the brain. Interestingly, in contrast to the
predominantly inhibitory actions of peripheral somatostatin, the activation of brain sst 2
signaling by intracerebroventricular injection of stable somatostatin agonists potently …