Role of myokines in the development of skeletal muscle insulin resistance and related metabolic defects in type 2 diabetes
L Garneau, C Aguer - Diabetes & metabolism, 2019 - Elsevier
Due to its mass, skeletal muscle is the major site of glucose uptake and an important tissue
in the development of type 2 diabetes (T2D). Muscles of patients with T2D are affected with
insulin resistance and mitochondrial dysfunction, which result in impaired glucose and fatty
acid metabolism. A well-established method of managing the muscle metabolic defects
occurring in T2D is physical exercise. During exercise, muscles contract and secrete factors
called myokines which can act in an autocrine/paracrine fashion to improve muscle energy …
in the development of type 2 diabetes (T2D). Muscles of patients with T2D are affected with
insulin resistance and mitochondrial dysfunction, which result in impaired glucose and fatty
acid metabolism. A well-established method of managing the muscle metabolic defects
occurring in T2D is physical exercise. During exercise, muscles contract and secrete factors
called myokines which can act in an autocrine/paracrine fashion to improve muscle energy …
