[HTML][HTML] Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase
GG Chiang, RT Abraham - Journal of Biological Chemistry, 2005 - ASBMB
The mammalian target of rapamycin (mTOR) coordinates cell growth with thegrowth factor
and nutrient/energy status of the cell. The phosphatidylinositol3-kinase-AKT pathway is
centrally involved in the transmission of mitogenicsignals to mTOR. Previous studies have
shown that mTOR is a direct substratefor the AKT kinase and identified Ser-2448 as the AKT
target site in mTOR. Inthis study, we demonstrate that rapamycin, a specific inhibitor of
mTORfunction, blocks serum-stimulated Ser-2448 phosphorylation and that this drugeffect is …
and nutrient/energy status of the cell. The phosphatidylinositol3-kinase-AKT pathway is
centrally involved in the transmission of mitogenicsignals to mTOR. Previous studies have
shown that mTOR is a direct substratefor the AKT kinase and identified Ser-2448 as the AKT
target site in mTOR. Inthis study, we demonstrate that rapamycin, a specific inhibitor of
mTORfunction, blocks serum-stimulated Ser-2448 phosphorylation and that this drugeffect is …