[HTML][HTML] Effects of GlyT1 inhibition on erythropoiesis and iron homeostasis in rats
M Winter, J Funk, A Körner, D Alberati, F Christen… - Experimental …, 2016 - Elsevier
Highlights•Glycine transporter 1 (GlyT1) inhibition reduces glycine uptake in erythrocyte
precursors.•Intracellular glycine depletion affects the rate of heme biosynthesis.•Reduction
in cellular hemoglobin manifests as a microcytic hypochromic anemia.•GlyT1-restricted
anemia does not suppress hepcidin synthesis.•Increased systemic iron acquisition does not
occur in response to GlyT1 inhibition.Glycine is a key rate-limiting component of heme
biosynthesis in erythropoietic cells, where the high intracellular glycine demand is primarily …
precursors.•Intracellular glycine depletion affects the rate of heme biosynthesis.•Reduction
in cellular hemoglobin manifests as a microcytic hypochromic anemia.•GlyT1-restricted
anemia does not suppress hepcidin synthesis.•Increased systemic iron acquisition does not
occur in response to GlyT1 inhibition.Glycine is a key rate-limiting component of heme
biosynthesis in erythropoietic cells, where the high intracellular glycine demand is primarily …