Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth
NN Khodarev, B Roizman, RR Weichselbaum - Clinical cancer research, 2012 - AACR
NN Khodarev, B Roizman, RR Weichselbaum
Clinical cancer research, 2012•AACRSTAT1 is activated by IFNs and other cell signals. Following activation, STAT1 is
translocated to the nuclei and activates transcription of IFN-stimulated genes. Although the
activation of STAT1 by IFNs is classically associated with antiviral defense and tumor-
suppressive functions, emerging data indicate that expression of the STAT1 pathway confers
cellular resistance to DNA-damaging agents and mediates aggressive tumor growth. Recent
advances in the development of Janus-activated kinase/Stat inhibitors and peptide inhibitors …
translocated to the nuclei and activates transcription of IFN-stimulated genes. Although the
activation of STAT1 by IFNs is classically associated with antiviral defense and tumor-
suppressive functions, emerging data indicate that expression of the STAT1 pathway confers
cellular resistance to DNA-damaging agents and mediates aggressive tumor growth. Recent
advances in the development of Janus-activated kinase/Stat inhibitors and peptide inhibitors …
Abstract
STAT1 is activated by IFNs and other cell signals. Following activation, STAT1 is translocated to the nuclei and activates transcription of IFN-stimulated genes. Although the activation of STAT1 by IFNs is classically associated with antiviral defense and tumor-suppressive functions, emerging data indicate that expression of the STAT1 pathway confers cellular resistance to DNA-damaging agents and mediates aggressive tumor growth. Recent advances in the development of Janus-activated kinase/Stat inhibitors and peptide inhibitors specific for individual Stat proteins may provide new insights into the controversial functions of this pathway. Clin Cancer Res; 18(11); 3015–21. ©2012 AACR.
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