Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

E Haldón, MC Nicasio, PJ Pérez - Organic & Biomolecular Chemistry, 2015 - pubs.rsc.org
E Haldón, MC Nicasio, PJ Pérez
Organic & Biomolecular Chemistry, 2015pubs.rsc.org
The reactions of organic azides and alkynes catalysed by copper species represent the
prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed
azide–alkyne cycloaddition), discovered in 2002, has been expanded since then to become
an excellent tool in organic synthesis. In this contribution the recent results described in the
literature since 2010 are reviewed, classified according to the nature of the catalyst
precursor: copper (I) or copper (II) salts or complexes, metallic or nano-particulated copper …
The reactions of organic azides and alkynes catalysed by copper species represent the prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed azide–alkyne cycloaddition), discovered in 2002, has been expanded since then to become an excellent tool in organic synthesis. In this contribution the recent results described in the literature since 2010 are reviewed, classified according to the nature of the catalyst precursor: copper(I) or copper(II) salts or complexes, metallic or nano-particulated copper and several solid-supported copper systems.
The Royal Society of Chemistry