[HTML][HTML] Theories and quantification of thymic selection

A Yates - Frontiers in immunology, 2014 - frontiersin.org
Frontiers in immunology, 2014frontiersin.org
The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing
randomly generated T cell receptors (TCR) and by a series of developmental and selection
steps that remove cells that are unresponsive or overly reactive to self-peptide–MHC
complexes. The challenge of understanding how the kinetics of T cell development and the
statistics of the selection processes combine to provide a diverse but self-tolerant T cell
repertoire has invited quantitative modeling approaches, which are reviewed here.
The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing randomly generated T cell receptors (TCR) and by a series of developmental and selection steps that remove cells that are unresponsive or overly reactive to self-peptide–MHC complexes. The challenge of understanding how the kinetics of T cell development and the statistics of the selection processes combine to provide a diverse but self-tolerant T cell repertoire has invited quantitative modeling approaches, which are reviewed here.
Frontiers