[HTML][HTML] ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells
X Yang, G Karsenty - Journal of Biological Chemistry, 2004 - ASBMB
Based on the analysis of a loss-of-function model, we recently showed that ATF4 regulates
osteoblast terminal differentiation and function and is implicated in the pathophysiology of
Coffin-Lowry syndrome. That study, however, did not address whether forced expression of
Atf4 in non-osteoblastic cells would lead to osteoblast-specific gene expression, one of the
most important features of a cell differentiation factor. To address this question we searched
for cell lines that would not express Atf4. Contrasting with the restricted pattern of its protein …
osteoblast terminal differentiation and function and is implicated in the pathophysiology of
Coffin-Lowry syndrome. That study, however, did not address whether forced expression of
Atf4 in non-osteoblastic cells would lead to osteoblast-specific gene expression, one of the
most important features of a cell differentiation factor. To address this question we searched
for cell lines that would not express Atf4. Contrasting with the restricted pattern of its protein …