Insulin‐induced microvascular recruitment in skin and muscle are related and both are associated with whole‐body glucose uptake
RI Meijer, MP De Boer, MR Groen, EC Eringa… - …, 2012 - Wiley Online Library
Microcirculation, 2012•Wiley Online Library
Please cite this paper as: Meijer RI, de Boer MP, Groen MR, Eringa EC, Rattigan S, Barrett
EJ, Smulders YM, Serne EH. Insulin‐induced microvascular recruitment in skin and muscle
are related and both are associated with whole‐body glucose uptake. Microcirculation 19:
494–500, 2012. Abstract Objective: Insulin‐induced capillary recruitment is considered a
determinant of insulin‐mediated glucose uptake. Insulin action on the microvasculature has
been assessed in skin; however, there is concern as to whether the vascular responses …
EJ, Smulders YM, Serne EH. Insulin‐induced microvascular recruitment in skin and muscle
are related and both are associated with whole‐body glucose uptake. Microcirculation 19:
494–500, 2012. Abstract Objective: Insulin‐induced capillary recruitment is considered a
determinant of insulin‐mediated glucose uptake. Insulin action on the microvasculature has
been assessed in skin; however, there is concern as to whether the vascular responses …
Please cite this paper as: Meijer RI, de Boer MP, Groen MR, Eringa EC, Rattigan S, Barrett EJ, Smulders YM, Serne EH. Insulin‐induced microvascular recruitment in skin and muscle are related and both are associated with whole‐body glucose uptake. Microcirculation 19: 494–500, 2012.
Abstract
Objective: Insulin‐induced capillary recruitment is considered a determinant of insulin‐mediated glucose uptake. Insulin action on the microvasculature has been assessed in skin; however, there is concern as to whether the vascular responses observed in skin reflect those in the muscle. We hypothesized that insulin‐induced capillary recruitment in skin would correlate with microvascular recruitment in muscle in a group of subjects displaying a wide variation in insulin sensitivity.
Methods: Capillary recruitment in skin was assessed using capillary videomicroscopy, and skeletal muscle microvascular recruitment (i.e., increase in MBV) was studied using CEU in healthy volunteers (n = 18, mean age: 30.6 ± 11.1 years). Both microvascular measurements were performed during saline infusion, and during a hyperinsulinemic euglycemic clamp.
Results: During hyperinsulinemia, capillary recruitment in skin was augmented from 58.1 ± 18.2% to 81.0 ± 23.9% (p < 0.0001). Hyperinsulinemia increased MBV in muscle from 7.00 (2.66–17.67) to 10.06 (2.70–41.81) units (p = 0.003). Insulin’s vascular effect in skin and muscle was correlated (r = 0.57). Insulin’s microvascular effects in skin and muscle showed comparable strong correlations with insulin‐mediated glucose uptake (r = 0.73 and 0.68, respectively).
Conclusions: Insulin‐augmented capillary recruitment in skin parallels insulin‐mediated microvascular recruitment in muscle and both are related to insulin‐mediated glucose uptake.
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