Murine UDP-GlcNAc: lysosomal enzyme N-acetylglucosamine-1-phosphotransferase lacking the γ-subunit retains substantial activity toward acid hydrolases
WS Lee, BJ Payne, CM Gelfman, P Vogel… - Journal of Biological …, 2007 - jbc.org
UDP-GlcNAc: lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-
phosphotransferase) mediates the first step in the synthesis of the mannose 6-phosphate
recognition marker on acid hydrolases. The transferase exists as anα 2 β 2 γ 2 hexameric
complex with the α-and β-subunits derived from a single precursor molecule. The catalytic
function of the transferase is attributed to the α-and β-subunits, whereas the γ-subunit is
believed to be involved in the recognition of a conformation-dependent protein determinant …
phosphotransferase) mediates the first step in the synthesis of the mannose 6-phosphate
recognition marker on acid hydrolases. The transferase exists as anα 2 β 2 γ 2 hexameric
complex with the α-and β-subunits derived from a single precursor molecule. The catalytic
function of the transferase is attributed to the α-and β-subunits, whereas the γ-subunit is
believed to be involved in the recognition of a conformation-dependent protein determinant …
