[HTML][HTML] The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
M Luhr, ML Torgersen, P Szalai, A Hashim… - Journal of Biological …, 2019 - ASBMB
Endoplasmic reticulum (ER) stress is thought to activate autophagy via unfolded protein
response (UPR)-mediated transcriptional up-regulation of autophagy machinery
components and modulation of microtubule-associated protein 1 light chain 3 (LC3). The
upstream UPR constituents pancreatic EIF2-α kinase (PERK) and inositol-requiring enzyme
1 (IRE1) have been reported to mediate these effects, suggesting that UPR may stimulate
autophagy via PERK and IRE1. However, how the UPR and its components affect …
response (UPR)-mediated transcriptional up-regulation of autophagy machinery
components and modulation of microtubule-associated protein 1 light chain 3 (LC3). The
upstream UPR constituents pancreatic EIF2-α kinase (PERK) and inositol-requiring enzyme
1 (IRE1) have been reported to mediate these effects, suggesting that UPR may stimulate
autophagy via PERK and IRE1. However, how the UPR and its components affect …