An electron microscopic analysis of gliogenesis in rat optic nerves
JE Vaughn - Zeitschrift für Zellforschung und mikroskopische …, 1969 - Springer
JE Vaughn
Zeitschrift für Zellforschung und mikroskopische Anatomie, 1969•SpringerThe development of neuroglia has been studied in rat optic nerves with the electron and
light microscopes. The main findings of this investigation are as follows: 1. Transitional forms
between the cell varieties present during development suggest a direct lineage from the
neuroectodermal matrix cells lining the lumen of the optic stalk to all neuroglial cell types.
There was no evidence of mesenchymal cell invasion, either from the meninges or blood
vessels, into optic nerve parenchyma. 2. One variety of undifferentiated cells, namely the …
light microscopes. The main findings of this investigation are as follows: 1. Transitional forms
between the cell varieties present during development suggest a direct lineage from the
neuroectodermal matrix cells lining the lumen of the optic stalk to all neuroglial cell types.
There was no evidence of mesenchymal cell invasion, either from the meninges or blood
vessels, into optic nerve parenchyma. 2. One variety of undifferentiated cells, namely the …
Summary
The development of neuroglia has been studied in rat optic nerves with the electron and light microscopes. The main findings of this investigation are as follows:
- 1. Transitional forms between the cell varieties present during development suggest a direct lineage from the neuroectodermal matrix cells lining the lumen of the optic stalk to all neuroglial cell types. There was no evidence of mesenchymal cell invasion, either from the meninges or blood vessels, into optic nerve parenchyma.
- 2. One variety of undifferentiated cells, namely the small glioblasts, may have the potential to either remain in the mitotic cycle giving rise to additional glioblasts, or to differentiate into either astrocytes or oligodendrocytes. Some small glioblasts are retained in fully mature rat optic nerves as a third type of neuroglia and these cells might be a source of the additional oligodendrocytes and/or astrocytes that arise within adult central nervous tissue.
- 3. Astrocytes begin to appear during fetal development. Oligodendrocytes first appear just prior to the time when myelination begins (i.e. 7–9 days postnatal). The early postnatal oligodendrocytes that are forming myelin sheaths are markedly different in appearance from those in mature nerves.
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