Activation of the unfolded protein response in response to endoplasmic reticulum stress
preserves cell viability and function under stressful conditions. Nevertheless, persistent,
unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate
stressed cells. Recent studies show that the unfolded protein response plays an important
role in the pathogenesis of various disorders of myelin, including multiples sclerosis,
Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher disease, vanishing white matter …