The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
ME Rinella, RM Green - Journal of hepatology, 2004 - Elsevier
Background/Aims: Non-alcoholic steatohepatitis is an important disease whose
pathophysiology remains incompletely understood, although in humans a strong association
with insulin resistance exists. Mice fed a methionine-choline deficient (MCD) diet develop
steatohepatitis, however the influence of insulin in this model is unknown. Methods: Male
FVB/NJ mice were fed the MCD, MCD control or chow diet for 10 or 28 days. Fasting
glucose, ALT, triglyceride and insulin was measured. Glucose tolerance tests (GTT) and …
pathophysiology remains incompletely understood, although in humans a strong association
with insulin resistance exists. Mice fed a methionine-choline deficient (MCD) diet develop
steatohepatitis, however the influence of insulin in this model is unknown. Methods: Male
FVB/NJ mice were fed the MCD, MCD control or chow diet for 10 or 28 days. Fasting
glucose, ALT, triglyceride and insulin was measured. Glucose tolerance tests (GTT) and …