CD3δ establishes a functional link between the T cell receptor and CD8
MA Doucey, L Goffin, D Naeher, O Michielin… - Journal of Biological …, 2003 - ASBMB
T cells expressing T cell receptor (TCR) complexes that lack CD3δ, either due to deletion of
the CD3δgene, or by replacement of the connecting peptide of the TCRα chain, exhibit
severely impaired positive selection and TCR-mediated activation of CD8 single-positive T
cells. Because the same defects have been observed in mice expressing no CD8β or
tailless CD8β, we examined whether CD3δ serves to couple TCR· CD3 with CD8. To this
end we used T cell hybridomas and transgenic mice expressing the T1 TCR, which …
the CD3δgene, or by replacement of the connecting peptide of the TCRα chain, exhibit
severely impaired positive selection and TCR-mediated activation of CD8 single-positive T
cells. Because the same defects have been observed in mice expressing no CD8β or
tailless CD8β, we examined whether CD3δ serves to couple TCR· CD3 with CD8. To this
end we used T cell hybridomas and transgenic mice expressing the T1 TCR, which …
