In therapeutic antibody discovery and early development, mice and cynomolgus monkey are
used as animal models to assess toxicity, efficacy and other properties of candidate
molecules. As more candidate antibodies are based on human immunoglobulin (IgG)
subclasses, many strategies are pursued to simulate the human system in the test animal.
However, translation rate from a successful preclinical trial to an approved drug is extremely
low. This may partly be due to differences in interaction of human IgG based candidate …