[HTML][HTML] Fc engineering approaches to enhance the agonism and effector functions of an anti-OX40 antibody
D Zhang, MV Goldberg, ML Chiu - Journal of Biological Chemistry, 2016 - ASBMB
Agonistic antibodies directed against immunostimulatory receptors belonging to the tumor
necrosis factor receptor (TNFR) superfamily are emerging as promising cancer
immunotherapies. Several Fc engineering approaches discovered recently can augment the
anti-tumor activities of TNFR antibodies by enhancing their agonistic activities and/or effector
functions. In this study, we compared these approaches for their effects on an anti-OX40
antibody. Both S267E/L328F and V12 mutations facilitated enhanced binding to FcγRIIB and …
necrosis factor receptor (TNFR) superfamily are emerging as promising cancer
immunotherapies. Several Fc engineering approaches discovered recently can augment the
anti-tumor activities of TNFR antibodies by enhancing their agonistic activities and/or effector
functions. In this study, we compared these approaches for their effects on an anti-OX40
antibody. Both S267E/L328F and V12 mutations facilitated enhanced binding to FcγRIIB and …