Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma
K McCauley, J Durack, R Valladares… - Journal of Allergy and …, 2019 - Elsevier
Background In infants, distinct nasopharyngeal bacterial microbiotas differentially associate
with the incidence and severity of acute respiratory tract infection and childhood asthma
development. Objective We hypothesized that distinct nasal airway microbiota structures
also exist in children with asthma and relate to clinical outcomes. Methods Nasal secretion
samples (n= 3122) collected after randomization during the fall season from children with
asthma (6-17 years, n= 413) enrolled in a trial of omalizumab (anti-IgE) underwent 16S …
with the incidence and severity of acute respiratory tract infection and childhood asthma
development. Objective We hypothesized that distinct nasal airway microbiota structures
also exist in children with asthma and relate to clinical outcomes. Methods Nasal secretion
samples (n= 3122) collected after randomization during the fall season from children with
asthma (6-17 years, n= 413) enrolled in a trial of omalizumab (anti-IgE) underwent 16S …