NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection

N Gill, MJ Chenoweth, EF Verdu, AA Ashkar - Cellular immunology, 2011 - Elsevier
Type I interferon (IFN) signalling, NK cells and NK cell-derived IFN-γ are critical in the early
control of genital HSV-2 infection. We have recently reported that NK cells are the source of
early IFN-γ in the genital tract in response to HSV-2. However, the response of NK cells to
genital HSV-2 infection is not well defined in the context of type I IFN signalling. Here we
show that HSV-2 replication was significantly higher in mice deficient in the type I IFN
receptor or NK cells compared to wild type controls. There was no detectable IFN-γ …