A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells
N Iijima, A Iwasaki - Science, 2014 - science.org
N Iijima, A Iwasaki
Science, 2014•science.orgCD8 tissue-resident memory T (TRM) cells provide efficient local control of viral infection, but
the role of CD4 TRM is less clear. Here, by using parabiotic mice, we show that a preexisting
pool of CD4 TRM cells in the genital mucosa was required for full protection from a lethal
herpes simplex virus 2 (HSV-2) infection. Chemokines secreted by a local network of
macrophages maintained vaginal CD4 TRM in memory lymphocyte clusters (MLCs),
independently of circulating memory T cells. CD4 TRM cells within the MLCs were enriched …
the role of CD4 TRM is less clear. Here, by using parabiotic mice, we show that a preexisting
pool of CD4 TRM cells in the genital mucosa was required for full protection from a lethal
herpes simplex virus 2 (HSV-2) infection. Chemokines secreted by a local network of
macrophages maintained vaginal CD4 TRM in memory lymphocyte clusters (MLCs),
independently of circulating memory T cells. CD4 TRM cells within the MLCs were enriched …
CD8 tissue-resident memory T (TRM) cells provide efficient local control of viral infection, but the role of CD4 TRM is less clear. Here, by using parabiotic mice, we show that a preexisting pool of CD4 TRM cells in the genital mucosa was required for full protection from a lethal herpes simplex virus 2 (HSV-2) infection. Chemokines secreted by a local network of macrophages maintained vaginal CD4 TRM in memory lymphocyte clusters (MLCs), independently of circulating memory T cells. CD4 TRM cells within the MLCs were enriched in clones that expanded in response to HSV-2. Our results highlight the need for vaccine strategies that enable establishment of TRM cells for protection from a sexually transmitted virus and provide insights as to how such a pool might be established.
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