The effect of complement C5a on mitochondrial functions of PC12 cells
RD Martinus, CJ Cook - Neuroreport, 2011 - journals.lww.com
C5a is thought to play a role during complement-activated neuronal apoptotic cell death in
the central nervous system. The mechanisms responsible are however not well-understood.
As mitochondria play a key role during apoptosis, we investigated mitochondria as a
potential target for C5a. Using PC12 cells, we demonstrated that exposure to C5a led to
inhibition of mitochondrial respiration, dehydrogenase and cytochrome c oxidase activities.
Interestingly, an increase in expression of the mitochondrial stress protein chaperonin 60 …
the central nervous system. The mechanisms responsible are however not well-understood.
As mitochondria play a key role during apoptosis, we investigated mitochondria as a
potential target for C5a. Using PC12 cells, we demonstrated that exposure to C5a led to
inhibition of mitochondrial respiration, dehydrogenase and cytochrome c oxidase activities.
Interestingly, an increase in expression of the mitochondrial stress protein chaperonin 60 …