[HTML][HTML] Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction
DM Cauvi, D Song, DE Vazquez, D Hawisher… - Journal of Biological …, 2012 - ASBMB
Sepsis is a major health problem in the United States with high incidence and elevated
patient care cost. Using an animal model of sepsis, cecum ligation, and puncture, we
observed that mice became rapidly hypothermic reaching a threshold temperature of 28° C
within 5–10 h after initiation of the insult, resulting in a reliable predictor of mortality, which
occurred within 30–72 h of the initial procedure. We also observed that the inflammatory
gene expression in lung and liver developed early within 1–2 h of the insult, reaching …
patient care cost. Using an animal model of sepsis, cecum ligation, and puncture, we
observed that mice became rapidly hypothermic reaching a threshold temperature of 28° C
within 5–10 h after initiation of the insult, resulting in a reliable predictor of mortality, which
occurred within 30–72 h of the initial procedure. We also observed that the inflammatory
gene expression in lung and liver developed early within 1–2 h of the insult, reaching …