Tertiary lymphoid organs in infection and autoimmunity

K Neyt, F Perros, CH GeurtsvanKessel, H Hammad… - Trends in …, 2012 - cell.com
K Neyt, F Perros, CH GeurtsvanKessel, H Hammad, BN Lambrecht
Trends in immunology, 2012cell.com
The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction
between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by
stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid
organs (TLOs) at sites of infection or chronic immune stimulation. This review focuses on the
molecular mechanisms of TLO formation and maintenance, the controversies surrounding
the nature of the inducing events, and the functions of these structures in infection …
The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation. This review focuses on the molecular mechanisms of TLO formation and maintenance, the controversies surrounding the nature of the inducing events, and the functions of these structures in infection, transplantation and autoimmunity.
cell.com