Impaired β-oxidation and altered complex lipid fatty acid partitioning with advancing CKD
F Afshinnia, TM Rajendiran, T Soni… - Journal of the …, 2018 - journals.lww.com
Studies of lipids in CKD, including ESRD, have been limited to measures of conventional
lipid profiles. We aimed to systematically identify 17 different lipid classes and associate the
abundance thereof with alterations in acylcarnitines, a metric of β-oxidation, across stages of
CKD. From the Clinical Phenotyping Resource and Biobank Core (CPROBE) cohort of 1235
adults, we selected a panel of 214 participants: 36 with stage 1 or 2 CKD, 99 with stage 3
CKD, 61 with stage 4 CKD, and 18 with stage 5 CKD. Among participants, 110 were men …
lipid profiles. We aimed to systematically identify 17 different lipid classes and associate the
abundance thereof with alterations in acylcarnitines, a metric of β-oxidation, across stages of
CKD. From the Clinical Phenotyping Resource and Biobank Core (CPROBE) cohort of 1235
adults, we selected a panel of 214 participants: 36 with stage 1 or 2 CKD, 99 with stage 3
CKD, 61 with stage 4 CKD, and 18 with stage 5 CKD. Among participants, 110 were men …