[HTML][HTML] Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex
Y Cai, J Jin, SK Swanson, MD Cole, SH Choi… - Journal of Biological …, 2010 - ASBMB
Human MOF (MYST1), a member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of
histone acetyltransferases (HATs), is the human ortholog of the Drosophila males absent on
the first (MOF) protein. MOF is the catalytic subunit of the male-specific lethal (MSL) HAT
complex, which plays a key role in dosage compensation in the fly and is responsible for a
large fraction of histone H4 lysine 16 (H4K16) acetylation in vivo. MOF was recently reported
to be a component of a second HAT complex, designated the non-specific lethal (NSL) …
histone acetyltransferases (HATs), is the human ortholog of the Drosophila males absent on
the first (MOF) protein. MOF is the catalytic subunit of the male-specific lethal (MSL) HAT
complex, which plays a key role in dosage compensation in the fly and is responsible for a
large fraction of histone H4 lysine 16 (H4K16) acetylation in vivo. MOF was recently reported
to be a component of a second HAT complex, designated the non-specific lethal (NSL) …