CREB1-binding protein (CBP) and p300 are believed to participate in the activities of
hundreds of different transcription factors (see Fig. 1). Current models suggest that the
binding of these coactivators to transcription factor activation domains positions histone
acetyltransferases (HATs) near specific nucleosomes in target gene promoter regions (for
review, see Ref. 1). Interactions with components of the general transcriptional machinery,
such as TFIID, TFIIB, and the RNA polymerase II holoenzyme (RNAPII) have also been …