AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats
M Klugmann, CW Symes, CB Leichtlein… - Molecular and Cellular …, 2005 - Elsevier
Homer proteins mediate molecular rearrangements leading to changes in spine
morphology. This points to a role of Homer in learning and memory. Homer 1c features both
the ligand binding domain and a coiled–coiled domain for self-multimerization. Homer 1a
lacks the coiled–coiled domain. Here, we report a new isoform which we termed 1g, lacking
the Homer ligand binding domain. We dissected the functional roles of the individual Homer
1 domains, encoded by Homer 1a, 1c, and 1g, in vivo. Recombinant adeno-associated virus …
morphology. This points to a role of Homer in learning and memory. Homer 1c features both
the ligand binding domain and a coiled–coiled domain for self-multimerization. Homer 1a
lacks the coiled–coiled domain. Here, we report a new isoform which we termed 1g, lacking
the Homer ligand binding domain. We dissected the functional roles of the individual Homer
1 domains, encoded by Homer 1a, 1c, and 1g, in vivo. Recombinant adeno-associated virus …