[HTML][HTML] Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines
We investigated the mechanisms by which chlorine (Cl 2) and its reactive byproducts inhibit
Na+-dependent alveolar fluid clearance (AFC) in vivo and the activity of amiloride-sensitive
epithelial Na+ channels (ENaC) by measuring AFC in mice exposed to Cl 2 (0–500 ppm for
30 min) and Na+ and amiloride-sensitive currents (I Na and I amil, respectively) across
Xenopus oocytes expressing human α-, β-, and γ-ENaC incubated with HOCl (1–2000 μm).
Both Cl 2 and HOCl-derived products decreased AFC in mice and whole cell and single …
Na+-dependent alveolar fluid clearance (AFC) in vivo and the activity of amiloride-sensitive
epithelial Na+ channels (ENaC) by measuring AFC in mice exposed to Cl 2 (0–500 ppm for
30 min) and Na+ and amiloride-sensitive currents (I Na and I amil, respectively) across
Xenopus oocytes expressing human α-, β-, and γ-ENaC incubated with HOCl (1–2000 μm).
Both Cl 2 and HOCl-derived products decreased AFC in mice and whole cell and single …