[HTML][HTML] Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability
AP Lillis, I Mikhailenko, DK Strickland - Journal of Thrombosis and …, 2005 - Elsevier
The low‐density lipoprotein (LDL) receptor related protein (LRP1 or LRP) is a large
endocytic receptor widely expressed in several tissues and known to play roles in areas as
diverse as lipoprotein metabolism, degradation of proteases, activation of lysosomal
enzymes and cellular entry of bacterial toxins and viruses. This member of the LDL receptor
superfamily is constitutively endocytosed from the membrane and recycled back to the cell
surface. Its many functions were long thought to involve its ability to bind over 30 different …
endocytic receptor widely expressed in several tissues and known to play roles in areas as
diverse as lipoprotein metabolism, degradation of proteases, activation of lysosomal
enzymes and cellular entry of bacterial toxins and viruses. This member of the LDL receptor
superfamily is constitutively endocytosed from the membrane and recycled back to the cell
surface. Its many functions were long thought to involve its ability to bind over 30 different …