Role of CD40-CD40-ligand interaction in Ig-isotype switching
R Fuleihan, N Ramesh, RS Geha - Current opinion in immunology, 1993 - Elsevier
R Fuleihan, N Ramesh, RS Geha
Current opinion in immunology, 1993•ElsevierIg-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal
delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the
CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the
role of CD40 and its ligand in Ig-isotype switching.
delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the
CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the
role of CD40 and its ligand in Ig-isotype switching.
Abstract
Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.
Elsevier