[HTML][HTML] Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis

AJ Van der Slot, AM Zuurmond, AFJ Bardoel… - Journal of Biological …, 2003 - ASBMB
The hallmark of fibrotic processes is an excessive accumulation of collagen. The deposited
collagen shows an increase in pyridinoline cross-links, which are derived from hydroxylated
lysine residues within the telopeptides. This change in cross-linking is related to irreversible
accumulation of collagen in fibrotic tissues. The increase in pyridinoline cross-links is likely
to be the result of increased activity of the enzyme responsible for the hydroxylation of the
telopeptides (telopeptide lysyl hydroxylase, or TLH). Although the existence of TLH has …