The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
JO Lundberg, E Weitzberg, MT Gladwin - Nature reviews Drug …, 2008 - nature.com
JO Lundberg, E Weitzberg, MT Gladwin
Nature reviews Drug discovery, 2008•nature.comThe inorganic anions nitrate (NO3−) and nitrite (NO2−) were previously thought to be inert
end products of endogenous nitric oxide (NO) metabolism. However, recent studies show
that these supposedly inert anions can be recycled in vivo to form NO, representing an
important alternative source of NO to the classical l-arginine–NO-synthase pathway, in
particular in hypoxic states. This Review discusses the emerging important biological
functions of the nitrate–nitrite–NO pathway, and highlights studies that implicate the …
end products of endogenous nitric oxide (NO) metabolism. However, recent studies show
that these supposedly inert anions can be recycled in vivo to form NO, representing an
important alternative source of NO to the classical l-arginine–NO-synthase pathway, in
particular in hypoxic states. This Review discusses the emerging important biological
functions of the nitrate–nitrite–NO pathway, and highlights studies that implicate the …
Abstract
The inorganic anions nitrate (NO3−) and nitrite (NO2−) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism. However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical l-arginine–NO-synthase pathway, in particular in hypoxic states. This Review discusses the emerging important biological functions of the nitrate–nitrite–NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulceration.
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