Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C

Q Lin, J Schwarz, C Bucana, E N. Olson - Science, 1997 - science.org
Q Lin, J Schwarz, C Bucana, E N. Olson
Science, 1997science.org
Members of the myocyte enhancer factor–2 (MEF2) family of MADS (MCM1, agamous,
deficiens, serum response factor)–box transcription factors bind an AT–rich DNA sequence
associated with muscle-specific genes. The murine MEF2C gene is expressed in heart
precursor cells before formation of the linear heart tube. In mice homozygous for a null
mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right
ventricle did not form, and a subset of cardiac muscle genes was not expressed. The …
Members of the myocyte enhancer factor–2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)–box transcription factors bind an A-T–rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.
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