[PDF][PDF] Liver transplantation for argininosuccinic aciduria: clinical, biochemical, and metabolic outcome
T Newnham, W Hardikar, K Allen… - Liver …, 2008 - Wiley Online Library
T Newnham, W Hardikar, K Allen, RM Wellard, C Hamilton, P Angus, R Jones, A Boneh
Liver Transplantation, 2008•Wiley Online LibraryWe report successful liver transplantation in a young adult with argininosuccinic aciduria but
without cirrhosis. Plasma amino acid profile normalized and brain magnetic resonance
spectroscopy indicated improved metabolism after transplantation. The general well‐being
of the patient and his quality of life improved. We suggest that orthotopic liver transplantation
should be considered for patients with argininosuccinic aciduria even in the absence of
cirrhosis, with the aim of correcting (at least in part) central nervous system metabolism …
without cirrhosis. Plasma amino acid profile normalized and brain magnetic resonance
spectroscopy indicated improved metabolism after transplantation. The general well‐being
of the patient and his quality of life improved. We suggest that orthotopic liver transplantation
should be considered for patients with argininosuccinic aciduria even in the absence of
cirrhosis, with the aim of correcting (at least in part) central nervous system metabolism …
Abstract
We report successful liver transplantation in a young adult with argininosuccinic aciduria but without cirrhosis. Plasma amino acid profile normalized and brain magnetic resonance spectroscopy indicated improved metabolism after transplantation. The general well‐being of the patient and his quality of life improved. We suggest that orthotopic liver transplantation should be considered for patients with argininosuccinic aciduria even in the absence of cirrhosis, with the aim of correcting (at least in part) central nervous system metabolism, thereby preventing further neurological deterioration. Liver Transpl 14:41–45, 2008. © 2007 AASLD.
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