The dual adverse effects of TGF-β secretion on tumor progression
JA Trapani - Cancer cell, 2005 - cell.com
Cancer cell, 2005•cell.com
When a cancer escapes the growth-inhibitory effects of TGF-β secreted by cancer cells
themselves or by cells in the local stroma, a further adverse outcome for the host is the
associated TGF-β-induced suppression of anticancer T cell immunity. In addition to the
previously described dampening of T cell activation and proliferation, TGF-β markedly and
directly suppresses the transcription of genes encoding multiple key proteins of the"
cytotoxic program" of CD8+ CTL, such as perforin and granzymes, cytotoxins that act …
themselves or by cells in the local stroma, a further adverse outcome for the host is the
associated TGF-β-induced suppression of anticancer T cell immunity. In addition to the
previously described dampening of T cell activation and proliferation, TGF-β markedly and
directly suppresses the transcription of genes encoding multiple key proteins of the"
cytotoxic program" of CD8+ CTL, such as perforin and granzymes, cytotoxins that act …
Summary
When a cancer escapes the growth-inhibitory effects of TGF-β secreted by cancer cells themselves or by cells in the local stroma, a further adverse outcome for the host is the associated TGF-β-induced suppression of anticancer T cell immunity. In addition to the previously described dampening of T cell activation and proliferation, TGF-β markedly and directly suppresses the transcription of genes encoding multiple key proteins of the "cytotoxic program" of CD8+ CTL, such as perforin and granzymes, cytotoxins that act through the granule exocytosis pathway. The findings described below suggest that TGF-β and its signaling pathways will be major targets for novel cancer therapeutics.
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