Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates inflammatory pain through the induction of heme oxygenase-1 in macrophages
M Hasegawa-Moriyama, T Kurimoto, M Nakama… - PAIN®, 2013 - Elsevier
Macrophage infiltration to inflammatory sites promotes tissue repair and may be involved in
pain hypersensitivity. Peroxisome proliferator-activated receptor (PPAR) γ signaling is
known to regulate polarity of macrophages, which are often referred to as proinflammatory
(M1) and antiinflammatory (M2) macrophages. We recently showed that the PPARγ agonist
rosiglitazone ameliorated the development of postincisional hyperalgesia by increasing the
influx of M2 macrophages to inflamed sites. It has been suggested that heme oxygenase …
pain hypersensitivity. Peroxisome proliferator-activated receptor (PPAR) γ signaling is
known to regulate polarity of macrophages, which are often referred to as proinflammatory
(M1) and antiinflammatory (M2) macrophages. We recently showed that the PPARγ agonist
rosiglitazone ameliorated the development of postincisional hyperalgesia by increasing the
influx of M2 macrophages to inflamed sites. It has been suggested that heme oxygenase …
