Stronger antinociceptive efficacy of opioids at the injured nerve trunk than at its peripheral terminals in neuropathic pain
D Labuz, H Machelska - The Journal of pharmacology and experimental …, 2013 - Elsevier
Activation of opioid receptors on peripheral sensory neurons has the potential for safe pain
control, as it lacks centrally mediated side effects. While this approach often only partially
suppressed neuropathic pain in animal models, opioids were mostly applied to animal paws
although neuropathy was induced at the nerve trunk. Here we aimed to identify the most
relevant peripheral site of opioid action for efficient antinociception in neuropathy. On days 2
and 14 following a chronic constriction injury (CCI) of the sciatic nerve in mice, we evaluated …
control, as it lacks centrally mediated side effects. While this approach often only partially
suppressed neuropathic pain in animal models, opioids were mostly applied to animal paws
although neuropathy was induced at the nerve trunk. Here we aimed to identify the most
relevant peripheral site of opioid action for efficient antinociception in neuropathy. On days 2
and 14 following a chronic constriction injury (CCI) of the sciatic nerve in mice, we evaluated …
