Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?
MJ Field, S Bramwell, J Hughes, L Singh - Pain, 1999 - Elsevier
In the present study, chronic constrictive injury (CCI model) of the sciatic nerve or tight
ligation of L5 and L6 spinal nerves (Chung model) produced both dynamic and static
components of mechanical allodynia in rats. The two responses were detected, respectively,
by lightly stroking the hind paw with cotton wool or application of pressure using von Frey
hairs. Animals with spinal nerve ligation developed both types of responses at a faster rate
compared to animals with the CCI. Morphine (1–3 mg/kg, sc) dose-dependently blocked …
ligation of L5 and L6 spinal nerves (Chung model) produced both dynamic and static
components of mechanical allodynia in rats. The two responses were detected, respectively,
by lightly stroking the hind paw with cotton wool or application of pressure using von Frey
hairs. Animals with spinal nerve ligation developed both types of responses at a faster rate
compared to animals with the CCI. Morphine (1–3 mg/kg, sc) dose-dependently blocked …