Opioid receptors are major actors in pain control and are broadly distributed throughout the
nervous system. A major challenge in pain research is the identification of key opioid
receptor populations within nociceptive pathways, which control physiological and
pathological pain. In particular, the respective contribution of peripheral vs. central receptors
remains unclear, and it has not been addressed by genetic approaches. To investigate the
contribution of peripheral delta opioid receptors in pain control, we created conditional …