Double in situ hybridization study on coexistence of μ-, δ-and κ-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia
M Minami, K Maekawa, K Yabuuchi, M Satoh - Molecular brain research, 1995 - Elsevier
Coexistence of the mRNA for each subtype of opioid receptor (OPR) with the mRNA for
preprotachykinin A (PPTA), a precursor protein of substance P (SP), in the rat dorsal root
ganglia was examined by double in situ hybridization technique. About 90% and 30% of
PPTA mRNA-positive neurons expressed μ-and κ-OPR mRNAs at high level, respectively.
However, only about 3% of PPTA mRNA-positive neurons expressed δ-OPR mRNA at high
level. These results suggest that μ-and κ-OPRs exist on most of and a part of the primary …
preprotachykinin A (PPTA), a precursor protein of substance P (SP), in the rat dorsal root
ganglia was examined by double in situ hybridization technique. About 90% and 30% of
PPTA mRNA-positive neurons expressed μ-and κ-OPR mRNAs at high level, respectively.
However, only about 3% of PPTA mRNA-positive neurons expressed δ-OPR mRNA at high
level. These results suggest that μ-and κ-OPRs exist on most of and a part of the primary …