The analgesic effects of local administration of opioid agonists into peripheral tissues in
alleviating pain have been well documented in both clinical and preclinical studies, although
few studies have examined their effects in neuropathic pain. In this study, we investigated
the anti-allodynic effects of peripherally acting delta opioid receptor (DOR) agonists in a rat
model of neuropathic pain. Peripheral nerve injury (PNI) produced a time-dependent
decrease in mechanical withdrawal thresholds that was attenuated by local administration …