Antinociceptive effects of interleukin-4,-10, and-13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats
ML Vale, JB Marques, CA Moreira, FAC Rocha… - The Journal of …, 2003 - Elsevier
The antinociceptive effects of interleukin (IL)-4,-10, and-13 were investigated in two different
experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1–5
ng/animal), IL-10 (0.4–10 ng/animal), or IL-13 (0.4–2.5 ng/animal) inhibited the writhing
response induced by the ip administration of acetic acid (53–89%) or zymosan (63–74%) in
mice, and the knee joint incapacitation induced by ia injection of zymosan (49–66%) in rats.
Neither of the cytokines affected the pain elicited in mice using the hot-plate test. This …
experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1–5
ng/animal), IL-10 (0.4–10 ng/animal), or IL-13 (0.4–2.5 ng/animal) inhibited the writhing
response induced by the ip administration of acetic acid (53–89%) or zymosan (63–74%) in
mice, and the knee joint incapacitation induced by ia injection of zymosan (49–66%) in rats.
Neither of the cytokines affected the pain elicited in mice using the hot-plate test. This …