Interleukin-4-and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease
SJ Van Dyken, RM Locksley - Annual review of immunology, 2013 - annualreviews.org
The macrophage, a versatile cell type prominently involved in host defense and immunity,
assumes a distinct state of alternative activation in the context of polarized type 2 immune
responses such as allergic inflammation and helminth infection. This alternatively activated
phenotype is induced by the canonical type 2 cytokines interleukin (IL)-4 and IL-13, which
mediate expression of several characteristic markers along with a dramatic shift in
macrophage metabolic pathways that influence surrounding cells and tissues. We discuss …
assumes a distinct state of alternative activation in the context of polarized type 2 immune
responses such as allergic inflammation and helminth infection. This alternatively activated
phenotype is induced by the canonical type 2 cytokines interleukin (IL)-4 and IL-13, which
mediate expression of several characteristic markers along with a dramatic shift in
macrophage metabolic pathways that influence surrounding cells and tissues. We discuss …