IL-4 in the brain: a cytokine to remember
SP Gadani, JC Cronk, GT Norris… - The journal of immunology, 2012 - journals.aai.org
IL-4 has been extensively studied in the context of its role in immunity. Accumulating
evidence indicates, however, that it also plays a critical role in higher functions of the normal
brain, such as memory and learning. In this review, we summarize current knowledge of the
basic immunology of IL-4, describe how and where this cytokine appears to operate in
normal brain function, and propose a hypothesis concerning its potential role in neurological
pathologies.
evidence indicates, however, that it also plays a critical role in higher functions of the normal
brain, such as memory and learning. In this review, we summarize current knowledge of the
basic immunology of IL-4, describe how and where this cytokine appears to operate in
normal brain function, and propose a hypothesis concerning its potential role in neurological
pathologies.
Abstract
IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.
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