The concept that the immune system can communicate with peripheral sensory neurons to
modulate pain is based mostly on documented interactions between opioid ligands and
receptors. Such findings may have broad implications for the development of safer pain
medication. Innovative strategies take into account that analgesics should be particularly
active in pathological states rather than producing a general suppression of the central
nervous system, as with conventional morphine-or cannabinoid-like drugs. Inflammation of …