[HTML][HTML] Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells

X Contreras, M Schweneker, CS Chen… - Journal of Biological …, 2009 - ASBMB
Human immunodeficiency virus (HIV) persists in a latent form in infected individuals treated
effectively with highly active antiretroviral therapy (HAART). In part, these latent proviruses
account for the rebound in viral replication observed after treatment interruption. A major
therapeutic challenge is to purge this reservoir. In this study, we demonstrate that
suberoylanilide hydroxamic acid (SAHA) reactivates HIV from latency in chronically infected
cell lines and primary cells. Indeed, P-TEFb, a critical transcription cofactor for HIV, is …