Functional analysis of human memory B-cell subpopulations: IgD+ CD27+ B cells are crucial in secondary immune response by producing high affinity IgM

Y Shi, K Agematsu, HD Ochs, K Sugane - Clinical immunology, 2003 - Elsevier
The number of memory B cells in peripheral blood has been assayed in various diseases by
using CD27 as a memory B-cell marker. However, the defining differences of characteristic
and function between the two memory B-cell subpopulations separated by immunoglobulin
(Ig) D expression remain to be clearly elucidated. We analyzed here IgD+ CD27+ B cells
(circulating B cells 2, cB2) and IgD− CD27+ memory B cells (cB3) in comparison with IgD+
CD27− naive B cells (cB1). cB2 were found to be morphologically similar to cB3 with …