Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly
B Weinberger, L Lazuardi, I Weiskirchner, M Keller… - Human immunology, 2007 - Elsevier
Despite general acceptance that immunologic changes are associated with aging and latent
infection with Cytomegalovirus (CMV), no clear-cut distinction has so far been made
between strictly age-related and CMV-induced changes. We therefore compared CD4+ and
CD8+ naïve (CD45RA+ CD28+), memory (CD45RA− CD28+), and effector (CD28−) T cells
in CMV-positive (n= 164) and CMV-negative (n= 87) elderly persons and correlated CD8+
and CD4+ effector T cells with other T-cell subpopulations. Percentages of CD8+ as well as …
infection with Cytomegalovirus (CMV), no clear-cut distinction has so far been made
between strictly age-related and CMV-induced changes. We therefore compared CD4+ and
CD8+ naïve (CD45RA+ CD28+), memory (CD45RA− CD28+), and effector (CD28−) T cells
in CMV-positive (n= 164) and CMV-negative (n= 87) elderly persons and correlated CD8+
and CD4+ effector T cells with other T-cell subpopulations. Percentages of CD8+ as well as …