Opinion: Virtual memory CD8 T cells and lymphopenia-induced memory CD8 T cells represent a single subset: Homeostatic memory T cells
M Pribikova, A Moudra, O Stepanek - Immunology Letters, 2018 - Elsevier
It is well established that lymphopenia induces the formation of the memory-phenotype T
cells without the exposure to foreign antigens. More recently, the memory-phenotype
antigen-inexperienced memory T cells were described in lymphoreplete mice and called
virtual memory T cells. In this review, we compare multiple aspects of the biology of
lymphopenia-induced memory T cells and virtual memory T cells, including cytokine
requirements, the role of T-cell receptor specificity in the differentiation process, gene …
cells without the exposure to foreign antigens. More recently, the memory-phenotype
antigen-inexperienced memory T cells were described in lymphoreplete mice and called
virtual memory T cells. In this review, we compare multiple aspects of the biology of
lymphopenia-induced memory T cells and virtual memory T cells, including cytokine
requirements, the role of T-cell receptor specificity in the differentiation process, gene …